...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International immunopharmacology >Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi).
【24h】

Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi).

机译：大型真菌真菌（宏真菌）领域的免疫调节剂和抗癌剂。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nowadays macrofungi are distinguished as important natural resources of immunomodulating and anticancer agents and with regard to the increase in diseases involving immune dysfunction, cancer, autoimmune conditions in recent years, applying such immunomodulator agents especially with the natural original is vital. These compounds belong mainly to polysaccharides especially beta-d-glucan derivates, glycopeptide/protein complexes (polysaccharide-peptide/protein complexes), proteoglycans, proteins and triterpenoids. Among polysaccharides, beta(1-->3)-d-glucans and their peptide/protein derivates and among proteins, fungal immunomodulatory proteins (Fips) have more important role in immunomodulating and antitumor activities. Immunomodulating and antitumor activity of these metabolites related to their effects to act of immune effecter cells such as hematpoietic stem cells, lymphocytes, macrophages, T cells, dendritic cells (DCs), and natural killer (NK) cells involved in the innate and adaptive immunity, resulting in the production of biologic response modifiers. In this review we have introduced the medicinal mushrooms' metabolites with immunomoduling and antitumor activities according to immunological evidences and then demonstrated their effects on innate and adaptive immunity and also the mechanisms of activation of immune responses and signaling cascade. In addition, their molecular structure and their relation to these activities have been shown. The important instances of these metabolites along with their immunomodulating and/or antitumor activities isolated from putative medicinal mushrooms are also introduced.
机译：如今，大型真菌已成为免疫调节剂和抗癌剂的重要天然资源，近年来，在涉及免疫功能障碍，癌症，自身免疫性疾病的疾病增加方面，尤其是与天然原药一起应用这类免疫调节剂至关重要。这些化合物主要属于多糖，尤其是β-d-葡聚糖衍生物，糖肽/蛋白质复合物（多糖-肽/蛋白质复合物），蛋白聚糖，蛋白质和三萜。在多糖中，β（1-> 3）-d-葡聚糖及其肽/蛋白质衍生物，在蛋白质中，真菌免疫调节蛋白（Fips）在免疫调节和抗肿瘤活性中具有更重要的作用。这些代谢物的免疫调节和抗肿瘤活性与其对免疫效应细胞（如造血干细胞，淋巴细胞，巨噬细胞，T细胞，树突状细胞（DC）和自然杀伤（NK）细胞）的作用有关，涉及先天和适应性免疫，从而产生生物反应调节剂。在这篇综述中，我们根据免疫学证据介绍了具有免疫调节和抗肿瘤活性的药用蘑菇代谢物，然后证明了它们对先天和适应性免疫的影响，以及免疫反应和信号级联反应的激活机制。此外，还显示了它们的分子结构及其与这些活性的关系。还介绍了这些代谢产物的重要实例以及从推定的药用蘑菇中分离出来的免疫调节和/或抗肿瘤活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号