Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

Ganguly S; Gastel JA; Weller JLSchwartz CJaffe HNamboodiri MACoon SLHickman ABRollag MObsil TBeauverger PFerry GBoutin JAKlein DC

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Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

机译：Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

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The daily rhythm in melatonin levels is controlled by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC ). Results presented here describe a regulatory/binding sequence in AANAT that encodes a cAMP-operated binding switch through which cAMP-regulated protein kinase-catalyzed phosphorylation RRHTLPAN --> RRHpTLPAN promotes formation of a complex with 14-3-3 proteins. Formation of this AANAT/14-3-3 complex enhances melatonin production by shielding AANAT from dephosphorylation and/or proteolysis and by decreasing the K(m) for 5-hydroxytryptamine (serotonin). Similar switches could play a role in cAMP signal transduction in other biological systems.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第14期|8083-8088|共6页
作者
Ganguly S; Gastel JA; Weller JLSchwartz CJaffe HNamboodiri MACoon SLHickman ABRollag MObsil TBeauverger PFerry GBoutin JAKlein DC;
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作者单位

Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480, USA.;

hylo.life.uiuc.edu;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Arylamine N Acetyltransferase physiology; Melatonin; Pineal Body; Tyrosine 3-Monooxygenase; 褪黑激素; 松果体; 酪氨酸单氧化酶;

Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

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