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MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?

机译：MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?

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摘要

In spite of enormous efforts and accumulated knowledge, our capabilities for tackling aging and age-related diseases (ARDs), and ultimately to promote longevity, are still very modest. What is lacking--essential data on key players, efficient analytic tools, or both? Here we discuss how the existing data may be integrated and analyzed in the context of microRNA (miRNA)-regulated protein-protein interaction networks. The proposed model highlighted: (1) The strong molecular links between aging, longevity, and ARDs; (2) the possibility and even the preferability of initiating longevity-promoting interventions in adult life; (3) the potentially important role for miRNA- (or small interfering RNA siRNA) mediated targeting of certain genes with features of antagonistic pleiotropy; (4) the superiority of systemic interventions to the common single-target approach in curing ARDs and promoting longevity.

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  • 来源
    《Rejuvenation research》 |2010年第3期|373-377|共5页
  • 作者

    Tacutu R; Budovsky A; Wolfson M Fraifeld VE;

  • 作者单位

    The Shraga Segal Department of Microbiology and Immunology, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel.;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 内科学;
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