Angiotensin II (ANG II) is locally produced in human skin and contributes to the reflex vasocon-striction (VC) response in aged but not young skin. We hypothesized that the exogenous ANG II-mediated VC response would be greater in older adults and would be affected by inhibition of adrenoreceptor or ANG II type II receptor (AT2R) pathways. Three microdialysis (MD) fibers were placed in the forearm skin of 11 young (26 ± 3 yr) and 11 older (68 ± 4 yr) individuals for perfusion of 1) Ringer solution (control), 2) adienoreceptor blockade with yohimbine + propranolol, and 3) AT2R inhibition with PD-123319.
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