Novel INHAT Repressor (NIR) is required for early lymphocyte development

Chi A. Ma; Antonia Pusso; Liming WuYongge ZhaoVictoria HoffmannLuigi D. NotarangeloB. J. FowlkesAshish Jain

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Novel INHAT Repressor (NIR) is required for early lymphocyte development

机译：Novel INHAT Repressor (NIR) is required for early lymphocyte development

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Novel inhibitor of histone acetyltransferase repressor (NIR) is a transcriptional corepressor with inhibitor of histone acetyltransferase activity and is a potent suppressor of p53. Although NIR deficiency in mice leads to early embryonic lethality, lymphoidrestricted deletion resulted in the absence of double-positive CD4+CD8+ thymocytes, whereas bone-marrow-derived B cells were arrested at the B220+CD19? pro-B-cell stage. V(D)J recombination was preserved in NIR-deficient DN3 double-negative thymocytes, suggesting that NIR does not affect p53 function in response to physiologic DNA breaks. Nevertheless, the combined deficiency of NIR and p53 provided rescue of DN3L double-negative thymocytes and their further differentiation to double- and single-positive thymocytes, whereas B cells in the marrow further developed to the B220+CD19+ pro-B-cell stage. Our results show that NIR cooperate with p53 to impose checkpoint for the generation of mature B and T lymphocytes.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第38期|13930-13935|共6页
作者
Chi A. Ma; Antonia Pusso; Liming WuYongge ZhaoVictoria HoffmannLuigi D. NotarangeloB. J. FowlkesAshish Jain;
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作者单位

Clinical Immunology Unit, Laboratory of Host Defenses, Bethesda, MD 20892;

Diagnostic and Research Services Branch, National Institutes of Health, Bethesda, MD 20892;

Department of Medicine, Children’s Hospital, Harvard Medical School, Boston, MA 02115Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
cell cycle; apoptosis; transcription;

Novel INHAT Repressor (NIR) is required for early lymphocyte development

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