SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

Lee Deokjae; An Jungeun; Park Young-UnLiaw HungjiunWoodgate RogerPark Jun HongMyung Kyungjae

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SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

机译：SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

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Many DNA repair proteins have additional functions other than their roles in DNA repair. In addition to catalyzing PCNA polyubiquitylation in response to the stalling of DNA replication, SHPRH has the additional function of facilitating rRNA transcription by localizing to the ribosomal DNA (rDNA) promoter in the nucleoli. SHPRH was recruited to the rDNA promoter using its plant homeodomain (PHD), which interacts with histone H3 when the fourth lysine of H3 is not trimethylated. SHPRH enrichment at the rDNA promoter was inhibited by cell starvation, by treatment with actinomycin D or rapamycin, or by depletion of CHD4. SHPRH also physically interacted with the RNA polymerase I complex. Taken together, we provide evidence that SHPRH functions in rRNA transcription through its interaction with histone H3 in a mammalian target of rapamycin (mTOR)-dependent manner.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2017年第17期|E3424-E3433|共10页
作者
Lee Deokjae; An Jungeun; Park Young-UnLiaw HungjiunWoodgate RogerPark Jun HongMyung Kyungjae;
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作者单位

NHGRI, Genome Instabil Sect, Genet & Mol Biol Branch, NIH, Bethesda, MD 20892 USA;

Inst Basic Sci, Ctr Genom Integr, Ulsan 689798, South Korea;

NICHHD, Lab Genom Integr, NIH, Bethesda, MD 20892 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
SHPRH; rRNA transcription; histone H3 methylation; mTOR;

SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

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