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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Gq/5-HT_(2c) receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice
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Gq/5-HT_(2c) receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice

机译：Gq/5-HT_(2c) receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice

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Serotonin 2c receptors (5-HT_(2c)-Rs) are drug targets for certain mental disorders, including schizophrenia, depression, and anxiety. 5-HT_(2c)-Rs are expressed throughout the brain, making it difficult to link behavioral changes to circuit specific receptor expression. Various 5-HT-Rs, including 5-HT_(2c)-Rs, are found in the dorsal raphe nucleus (DRN); however, the function of 5-HT_(2c)-Rs and their influence on the serotonergic signals mediating mood disorders remain unclear. To investigate the role of 5-HT_(2c)-Rs in the DRN in mice, we developed a melanopsin-based optogenetic probe for activation of Gq signals in cellular domains, where 5-HT_(2c)-Rs are localized. Our results demonstrate that precise temporal control of Gq signals in 5-HT_(2c)-R domains in GABAergic neurons upstream of 5-HT neurons provides negative feedback regulation of serotonergic firing to modulate anxiety-like behavior in mice.

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