Tonic GABA_A conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network

Ivan Pavlov; Leonid P. Savtchenko; Inseon SongJaeyeon KooAlexey PimashkinDmitri A. RusakovAlexey Semyanov

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Tonic GABA_A conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network

【24h】

Tonic GABA_A conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network

机译：Tonic GABA_A conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

The spiking output of interneurons is key for rhythm generation in the brain. However, what controls interneuronal firing remains incompletely understood. Here we combine dynamic clamp experiments with neural network simulations to understand how tonic GABA_A conductance regulates the firing pattern of CA3 interneurons. In baseline conditions, tonic GABA_A depolarizes these cells, thus exerting an excitatory action while also reducing the excitatory postsynaptic potential (EPSP) amplitude through shunting. As a result, the emergence of weak tonic GABA_A conductance transforms the interneuron firing pattern driven by individual EPSPs into a more regular spiking mode determined by the cell intrinsic properties. The increased regularity of spiking parallels stronger synchronization of the local network. With further increases in tonic GABA_A conductance the shunting inhibition starts to dominate over excitatory actions and thus moderates interneuronal firing. The remaining spikes tend to follow the timing of suprathreshold EPSPs and thus become less regular again. The latter parallels a weakening in network synchronization. Thus, our observations suggest that tonic GABA_A conductance can bidirectionally control brain rhythms through changes in the excitability of interneurons and in the temporal structure of their firing patterns.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第1期|504-509|共6页
作者
Ivan Pavlov; Leonid P. Savtchenko; Inseon SongJaeyeon KooAlexey PimashkinDmitri A. RusakovAlexey Semyanov;
展开▼
作者单位

Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, University College London, London WC1N 3BG, United Kingdom;

RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan;

Department of Neurodynamics and Neurobiology, University of Nizhny Novgorod, Nizhny Novgorod 603950, Russia;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
tonic conductance; extrasynaptic signaling; oscillations;

Tonic GABA_A conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network

摘要

著录项

相关主题

期刊订阅