H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease

Sahaf B.; Yang Y.; Arai S.Herzenberg L.A.Miklos D.B.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease

【24h】

H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease

机译：H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

B cells are known to play an important role in pathogenesis of human chronic graft vs. host disease (cGVHD). Our group has previously shown that IgG allo-antibodies recognize Y chromosomeencoded proteins (H-Y) and a dominant H-Y epitope, DEAD box protein (DBY-2) detectable 6.12 mo after transplant in male patients who receive grafts from female donors (F→M) hematopoietic cell transplantation (HCT). Here we present FACS studies of peripheral blood mononuclear cells collected 6 mo after transplant showing that 16 of 28 (57) F→M HCT patients have circulating donor B cells that express B-cell receptor (mainly IgM and Igα) specific for DBY-2. The detection of these DBY-2 B cells 6 mo after HCT are associated with cGVHD development (P = 0.004). Specifically, 15 of 16 F→M with DBY-2 B cells developed cGVHD. In contrast, cGVHD developed in only 5 of the 12 who did not have DBY-2 B cells detected. This demonstrates circulating human B cells binding an alloantigen (DBY-2) and that these DBY-2.specific B cells appear before development of cGVHD in roughly half of the F→M patients. Our study suggests that detection of anti.DBY-2 B cells may predict cGVHD and that this prediction may have clinical utility. Validation of this hypothesis will require larger prospective studies.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第8期|3005-3010|共6页
作者
Sahaf B.; Yang Y.; Arai S.Herzenberg L.A.Miklos D.B.;
展开▼
作者单位

Division of Blood and Marrow Transplantation, Department of Medicine, Stanford, CA 94305, United States;

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, United States;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Allogeneic; Antigen-specific B cells; DDX3Y; Transplantation;

H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease

摘要

著录项

相关主题

期刊订阅