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>Plasma elimination and urinary excretion of procaine after administration of different products to Standardbred mares
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Plasma elimination and urinary excretion of procaine after administration of different products to Standardbred mares
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机译：Plasma elimination and urinary excretion of procaine after administration of different products to Standardbred mares
SummaryPlasma and urinary concentrations of procaine were examined in Standardbred mares after subcutaneous administration of various doses (80 mg to 1600 mg) of procaine hydrochloride. Regardless of dose, peak plasma procaine values occurred within 1 h, but remained detectable in a dose‐dependent manner, with procaine present at 1 h with the 80 mg dose and 6 h at the 1600 mg dose. Similarly, peak urinary procaine concentrations were attained within 1.5 to 3 h, irrespective of dose, while detection time was dose‐dependent, being 23 h for 80–200 mg doses but as long as 30–54 h with the 1600 mg dose. When mares were given a single intramuscular injection of a penicillin G‐procaine preparation (Ethacillin, Cillimycin, Penamycin, Derapen A, Azimycin or Diathal), peak plasma procaine concentrations varied and were reached from 10 min to 3 h in all cases, with detection from 3 to 20 h after drug administration. Although the peak urinary levels of procaine occurred between 30 mins and 6 h, detection in urine in most cases was as long as 78–120 h except for Diathal for which detection was limited to 54 h. Daily administration of a penicillin G‐procaine preparation (Pen‐Di‐Strep) for 5 days produced a biphasic peak in plasma procaine at 3 and at 6–9 h with detection from 16 to 23 h after drug treatment. Although peak urinary procaine values were reached at similar times after single or multiple injections, the duration of detection was markedly longer (425 h) after the multiple‐dose regimen. Plasma procaine concentrations could not be detected after topical (Special Formula 17900) or oral (Pro‐Pen Feed Mix) penicillin G‐procaine administration but procaine was detected in urine at 30 h with the topical and at 54
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