ABSTRACT—Cultured murine Kupffer cells were tested for their ability to bind TNP‐sensitized erythrocytes coated with IgA myeloma proteins (MOPC 315460) which have high affinity for TNP ligands, and to ingest TNP‐enzyme‐IgA soluble immune complexes. In these experimental conditions, 6–18 of Kupffer cells were found to express surface binding sites for IgA, a feature they share with lymphocytes and granulocytes. This functional property, also displayed by circulating monocytes, is thus maintained in liver‐residing macrophages, and may contribute to the regulation of immune response to gut‐der
展开▼
