Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons

Tabuchi M.; Sakurai T.; Mitsuno H.Namiki S.Minegishi R.Shiotsuki T.Uchino K.Sezutsu H.Tamura T.Haupt S.S.Nakatani K.Kanzaki R.

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Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons

机译：Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons

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The olfactory system of male moths has an extreme sensitivity with the capability to detect and recognize conspecific pheromones dispersed and greatly diluted in the air. Just 170 molecules of the silkmoth (Bombyx mori) sex pheromone bombykol are sufficient to induce sexual behavior in the male. However, it is still unclear how the sensitivity of olfactory receptor neurons (ORNs) is relayed through the brain to generate high behavioral responsiveness. Here, we show that ORN activity that is subthreshold in terms of behavior can be amplified to suprathreshold levels by temporal integration in antennal lobe projection neurons (PNs) if occurring within a specific time window. To control ORN inputs with high temporal resolution, channelrhodopsin-2 was genetically introduced into bombykol-responsive ORNs. Temporal integration in PNs was only observed for weak inputs, but not for strong inputs. Pharmacological dissection revealed that GABAergic mechanisms inhibit temporal integration of strong inputs, showing that GABA signaling regulates PN responses in a stimulus-dependent fashion. Our results show that boosting of the PNs' responses by temporal integration of olfactory information occurs specifically near the behavioral threshold, effectively defining the lower bound for behavioral responsiveness.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第38期|15455-15460|共6页
作者
Tabuchi M.; Sakurai T.; Mitsuno H.Namiki S.Minegishi R.Shiotsuki T.Uchino K.Sezutsu H.Tamura T.Haupt S.S.Nakatani K.Kanzaki R.;
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作者单位

Department of Advanced Interdisciplinary Studies, Graduate School of Engineering, University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan;

Research Center for Advanced Science and Technology, University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan;

National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, JapanGraduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Olfaction; Optogenetics; Pheromone orientation behavior; Transgenic silkmoth;

Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons

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