Thermal activities of 6-gingerol, 8-gingerol and 6-shogaol on the potentiation of mitochondria thermogenesis based on microcalorimetry

Yang Zhirui; Zhang Dingkun; Zhang YamingWu MingquanLiu HonghongHan XueZheng QuanfuHuang YinqiuChen ChangZhang LuYan DanZhao YanLingXiao Xiaohe

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Thermal activities of 6-gingerol, 8-gingerol and 6-shogaol on the potentiation of mitochondria thermogenesis based on microcalorimetry

机译：Thermal activities of 6-gingerol, 8-gingerol and 6-shogaol on the potentiation of mitochondria thermogenesis based on microcalorimetry

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摘要

Zingiberis Rhizoma is a typical Chinese herb in 'hot' property. Nowadays, increasing attention has been aroused for its essential role in both health care and treatment of 'cold' syndrome. And research about characteristics of Zingiberis Rhizoma is able to provide an important reference for its deeper understand and successful clinic application. However, cognition level about the 'hot' property of Zingiberis Rhizoma is superficial, and mechanism behind the 'hot' presentation is still elusive and unclear. In this study, the 'hot' property of Zingiberis Rhizoma was investigated at a monomer level with assistance of microcalorimetry, an objective and sensitive method in evaluating biological activity. Three bioactive compounds including 6-gingerol, 8-gingerol and 6-shogaol were selected, and their thermal activities were explored with mitochondria as target. The power-time curves were recorded, and five thermal parameters (k, P (max), T (max), Q and P (av)) were obtained. With PCA, P (av) was calculated to be the main parameter to measure the bioactivities of 6-gingerol, 8-gingerol and 6-shogaol. Finally, the bioactivities of three subjects were compared with sequence to be 6-gingerol > 8-gingerol > 6-shogaol. Generally, our study is promising to offer a reference to the research about characteristics of Zingiberis Rhizoma or other herbs and is of great interest for clinic practice.

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来源
《Journal of thermal analysis and calorimetry》 |2017年第2期|1787-1795|共9页
作者
Yang Zhirui; Zhang Dingkun; Zhang YamingWu MingquanLiu HonghongHan XueZheng QuanfuHuang YinqiuChen ChangZhang LuYan DanZhao YanLingXiao Xiaohe;
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作者单位

Peoples Liberat Army, Dept Pharm, Hosp 302, Beijing 100039, Peoples R China;

Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China;

Peoples Liberat Army, China Mil Inst Chinese Med, Hosp 302, Beijing 100039, Peoples R ChinaPeoples Liberat Army, Dept Int Ctr Liver Dis Treatment, Hosp 302, Beijing 100039, Peoples R ChinaCapital Med Univ, Beijing Shijitan Hosp, Dept Pharm, Beijing 100038, Peoples R China;

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正文语种英语
中图分类物理化学（理论化学）、化学物理学;
关键词
6-Gingerol; Thermal activity; Mitochondria thermogenesis; Microcalorimetry;

Thermal activities of 6-gingerol, 8-gingerol and 6-shogaol on the potentiation of mitochondria thermogenesis based on microcalorimetry

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