Minimal and RNA-free RNase P in Aquifex aeolicus

Nickel Astrid I.; Waeber Nadine B.; Goessringer MarkusLechner MarcusLinne UweToth UrsulaRossmanith WalterHartmann Roland K.

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Minimal and RNA-free RNase P in Aquifex aeolicus

机译：Minimal and RNA-free RNase P in Aquifex aeolicus

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RNase P is an essential tRNA-processing enzyme in all domains of life. We identified an unknown type of protein-only RNase P in the hyperthermophilic bacterium Aquifex aeolicus: Without an RNA subunit and the smallest of its kind, the 23-kDa polypeptide comprises a metallonuclease domain only. The protein has RNase P activity in vitro and rescued the growth of Escherichia coli and Saccharomyces cerevisiae strains with inactivations of their more complex and larger endogenous ribonucleoprotein RNase P. Homologs of Aquifex RNase P (HARP) were identified in many Archaea and some Bacteria, of which all Archaea and most Bacteria also encode an RNA-based RNase P; activity of both RNase P forms from the same bacterium or archaeon could be verified in two selected cases. Bioinformatic analyses suggest that A. aeolicus and related Aquificaceae likely acquired HARP by horizontal gene transfer from an archaeon.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2017年第42期|11121-11126|共6页
作者
Nickel Astrid I.; Waeber Nadine B.; Goessringer MarkusLechner MarcusLinne UweToth UrsulaRossmanith WalterHartmann Roland K.;
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作者单位

Philipps Univ Marburg, Inst Pharmaceut Chem, D-35037 Marburg, Germany;

Philipps Univ Marburg, Fac Chem, Mass Spectrometry, D-35032 Marburg, Germany;

Med Univ Vienna, Ctr Anat & Cell Biol, A-1090 Vienna, Austria;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
protein-only RNase P; Aquifex aeolicus; tRNA processing; HARP;

Minimal and RNA-free RNase P in Aquifex aeolicus

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