Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection

Tregoning J.S.; Wang B.L.; McDonald J.U.Yamaguchi Y.Harker J.A.Goritzka M.Johansson C.Bukreyev A.Collins P.L.Openshaw P.J.

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Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection

机译：Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection

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Respiratory syncytial virus (RSV) infects most children in the first year of life and is a major single cause of hospitalization in infants and young children. There is no effective vaccine, and antibody generated by primary neonatal infection is poorly protective against reinfection even with antigenically homologous viral strains. Studying the immunological basis of these observations in neonatal mice, we found that antibody responses to infection were low and unaffected by CD4 depletion, in contrast with adult mice, which had stronger CD4-dependent antibody responses. Natural killer cell depletion or codepletion of CD4~+ and CD8~+ cells during neonatal RSV infection caused a striking increase in anti-RSV antibody titer. These cells are major sources of the cytokine IFN-γ, and blocking IFN-γ also enhanced RSV-specific antibody responses in neonates. In addition, infection with a recombinant RSV engineered to produce IFN-γ reduced antibody titer, confirming that IFN-γ plays a pivotal role in inhibition of antibody responses after neonatal infection. These unexpected findings show that the induction of a strong cellular immune response may limit antibody responses in early life and that vaccines that induce IFN-γ-secreting cells might, in some situations, be less protective than those that do not.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第14期|5576-5581|共6页
作者
Tregoning J.S.; Wang B.L.; McDonald J.U.Yamaguchi Y.Harker J.A.Goritzka M.Johansson C.Bukreyev A.Collins P.L.Openshaw P.J.;
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作者单位

Mucosal Infection and Immunity Group, Section of Infectious Diseases, Department of Medicine, London W2 1PG, United Kingdom;

Department of Respiratory Medicine, Centre for Respiratory Infection, Imperial College London, London W2 1PG, United Kingdom;

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Bronchiolitis; Lung infection; Viral infection;

Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection

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