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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes
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LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes

机译：LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes

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摘要

Long-term potentiation (LTP) is a persistent strengthening of synaptic transmission in the brain and is arguably the most compelling cellular and molecular model for learning and memory. Previous work found that both AMPA receptors and exogenously expressed kainate receptors are equally capable of expressing LTP, despite their limited homology and their association with distinct auxiliary subunits, indicating that LTP is far more promiscuous than previously thought. What might these two subtypes of glutamate receptor have in common? Using a single-cell molecular replacement strategy, we demonstrate that the AMPA receptor auxiliary subunit TARP gamma-8, via its PDZ-binding motif, is indispensable for both basal synaptic transmission and LTP. Remarkably, kainate receptors and their auxiliary subunits Neto proteins share the same requirement of PDZ-binding domains for synaptic trafficking and LTP. Together, these results suggest that a minimal postsynaptic requirement for LTP is the PDZ binding of glutamate receptors/auxiliary subunits to PSD scaffolding proteins.

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