Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

Li B.; Sher D.; Kelly L.Shi Y.Huang K.Knerr P.J.Joewono I.Rusch D.Chisholm S.W.Van Der Donk W.A.

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Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

机译：Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

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Our understanding of secondary metabolite production in bacteria has been shaped primarily by studies of attached varieties such as symbionts, pathogens, and soil bacteria. Here we show that a strain of the single-celled, planktonic marine cyanobacterium Prochlorococcus - which conducts a sizable fraction of photosynthesis in the oceans - produces many cyclic, lanthionine-containing peptides (lantipeptides). Remarkably, in Prochlorococcus MIT9313 a single promiscuous enzyme transforms up to 29 different linear ribosomally synthesized peptides into a library of polycyclic, conformationally constrained products with highly diverse ring topologies. Genes encoding this system are found in variable abundances across the oceans - with a hot spot in a Galapagos hypersaline lagoon - suggesting they play a habitat- and/or community-specific role. The extraordinarily efficient pathway for generating structural diversity enables these cyanobacteria to produce as many secondary metabolites as model antibiotic-producing bacteria, but with much smaller genomes.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第23期|10430-10435|共6页
作者
Li B.; Sher D.; Kelly L.Shi Y.Huang K.Knerr P.J.Joewono I.Rusch D.Chisholm S.W.Van Der Donk W.A.;
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作者单位

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, United States;

Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, United States;

J. Craig Venter Institute, Rockville, MD 20850, United StatesDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United StatesDepartment of Biochemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Combinatorial biosynthesis; Global ocean survey metagenome; Lantibiotic; Synechococcus;

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

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