Functional changes of the reward system underlie blunted response to social gaze in cocaine users

Katrin H. Preller; Marcus Herdener; Leonhard SchilbachPhilipp St?mpfliLea M. HulkaMatthias VonmoosNina IngoldKai VogeleyPhilippe N. ToblerErich SeifritzBoris B. Quednow

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Functional changes of the reward system underlie blunted response to social gaze in cocaine users

机译：Functional changes of the reward system underlie blunted response to social gaze in cocaine users

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Social interaction deficits in drug users likely impede treatment, increase the burden of the affected families, and consequently contribute to the high costs for society associated with addiction. Despite its significance, the neural basis of altered social interaction in drug users is currently unknown. Therefore, we investigated basal social gaze behavior in cocaine users by applying behavioral, psychophysiological, and functional brain-imaging methods. In study I, 80 regular cocaine users and 63 healthy controls completed an interactive paradigm in which the participants' gaze was recorded by an eye-tracking device that controlled the gaze of an anthropomorphic virtual character. Valence ratings of different eye-contact conditions revealed that cocaine users show diminished emotional engagement in social interaction, which was also supported by reduced pupil responses. Study II investigated the neural underpinnings of changes in social reward processing observed in study I. Sixteen cocaine users and 16 controls completed a similar interaction paradigm as used in study I while undergoing functional magnetic resonance imaging. In response to social interaction, cocaine users displayed decreased activation of the medial orbitofrontal cortex, a key region of reward processing. Moreover, blunted activation of themedial orbitofrontal cortex was significantly correlated with a decreased social network size, reflecting problems in real-life social behavior because of reduced social reward. In conclusion, basic social interaction deficits in cocaine users as observed here may arise from altered social reward processing. Consequently, these results point to the importance of reinstatement of social reward in the treatment of stimulant addiction.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第7期|2842-2847|共6页
作者
Katrin H. Preller; Marcus Herdener; Leonhard SchilbachPhilipp St?mpfliLea M. HulkaMatthias VonmoosNina IngoldKai VogeleyPhilippe N. ToblerErich SeifritzBoris B. Quednow;
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作者单位

Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland;

Department of Psychiatry, University of Cologne, 50937 Cologne, Germany;

Department of Economics, University of Zurich, 8006 Zurich, Switzerland;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
joint attention; reinforcement; social cognition; dopamine; social functioning;

Functional changes of the reward system underlie blunted response to social gaze in cocaine users

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