Macronutrient balance, reproductive function, and lifespan in aging mice

Solon-Biet Samantha M.; Walters Kirsty A.; Simanainen Ulla K.McMahon Aisling C.Ruohonen KariBallard John William O.Raubenheimer DavidHandelsman David J.Le Couteur David G.Simpson Stephen J.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Macronutrient balance, reproductive function, and lifespan in aging mice

【24h】

Macronutrient balance, reproductive function, and lifespan in aging mice

机译：Macronutrient balance, reproductive function, and lifespan in aging mice

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

In invertebrates, reproductive output and lifespan are profoundly impacted by dietary macronutrient balance, with these traits achieving their maxima on different diet compositions, giving the appearance of a resource-based tradeoff between reproduction and longevity. For the first time in a mammal, to our knowledge, we evaluate the effects of dietary protein (P), carbohydrate (C), fat (F), and energy (E) on lifespan and reproductive function in aging male and female mice. We show that, as in invertebrates, the balance of macronutrients has marked and largely opposing effects on reproductive and longevity outcomes. Mice were provided ad libitum access to one of 25 diets differing in P. C, F, and E content, with reproductive outcomes assessed at 15 months. An optimal balance of macronutrients exists for reproductive function, which, for most measures, differs from the diets that optimize lifespan, and this response differs with sex. Maximal longevity was achieved on diets containing a P:C ratio of 1:13 in males and 1:11 for females. Diets that optimized testes mass and epididymal sperm counts (indicators of gamete production) contained a higher P:C ratio (1:1) than those that maximized lifespan. In females, uterine mass (an indicator of estrogenic activity) was also greatest on high P:C diets (1:1) whereas ovarian follicle number was greatest on P:C 3:1 associated with high-F intakes. By contrast, estrous cycling was more likely in mice on lower P:C (1:8), and the number of corpora lutea, indicative of recent ovulations, was greatest on P:C similar to those supporting greatest longevity (1:11).

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2015年第11期|3481-3486|共6页
作者
Solon-Biet Samantha M.; Walters Kirsty A.; Simanainen Ulla K.McMahon Aisling C.Ruohonen KariBallard John William O.Raubenheimer DavidHandelsman David J.Le Couteur David G.Simpson Stephen J.;
展开▼
作者单位

Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia;

Univ Sydney, Concord Hosp, ANZAC Res Inst, Sydney, NSW 2139, Australia;

EWOS Innovat, N-4327 Sandnes, NorwayUniv New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
aging; macronutrients; lifespan; reproduction; nutrition;

Macronutrient balance, reproductive function, and lifespan in aging mice

摘要

著录项

相关主题

期刊订阅