Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

Camporez Joao-Paulo G.; Petersen Max C.; Abudukadier AbuliziMoreira Gabriela V.Jurczak Michael J.Friedman GlennHaqq Christopher M.Petersen Kitt FalkShulman Gerald I.

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Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

机译：Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

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Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological and pathophysiological processes, including normal aging. There are no approved therapies for sarcopenia, but the antihypertrophic myokine myostatin is a potential therapeutic target. Here, we show that treatment of young and old mice with an anti-myostatin antibody (ATA 842) for 4 wk increased muscle mass and muscle strength in both groups. Furthermore, ATA 842 treatment also increased insulin-stimulated whole body glucose metabolism in old mice, which could be attributed to increased insulin-stimulated skeletal muscle glucose uptake as measured by a hyperinsulinemic-euglycemic clamp. Taken together, these studies provide support for pharmacological inhibition of myostatin as a potential therapeutic approach for age-related sarcopenia and metabolic disease.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2016年第8期|2212-2217|共6页
作者
Camporez Joao-Paulo G.; Petersen Max C.; Abudukadier AbuliziMoreira Gabriela V.Jurczak Michael J.Friedman GlennHaqq Christopher M.Petersen Kitt FalkShulman Gerald I.;
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作者单位

Yale Univ, Sch Med, Dept Internal Med, 333 Cedar St, New Haven, CT 06520 USA;

Univ Pittsburgh, Dept Med, Div Endocrinol & Metab, 930 Scaife Hall, Pittsburgh, PA 15261 USA;

Atara Biotherapeut, Westlake Village, CA 91363 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
aging; myostatin; muscle mass; insulin resistance; sarcopenia;

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

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