The results of a preliminary immunocytochemical investigation on the subcommissural organ (SCO) in rats show that (1) Reissner's fiber (RF) or essential compounds of the RF are produced by the SCO, (2) the immunoreactive material is produced in the epithelial cells of the SCO as well as in the hypendymal cells, and (3) the immunoreactive material of the SCO belongs to a category of endogenous peptides to date not demonstrable immunocytochemically in other brain structures.
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