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外文期刊>American Journal of Physiology
>miR-222 represses expression of zipcode binding protein-1 and phospholipase C-gamma1 in intestinal epithelial cells
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miR-222 represses expression of zipcode binding protein-1 and phospholipase C-gamma1 in intestinal epithelial cells
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机译：miR-222 represses expression of zipcode binding protein-1 and phospholipase C-gamma1 in intestinal epithelial cells
Ectopically expressed miR-222 precursor destabilized the ZBP1 and PLCyl mRNAs and consequently lowered the levels of cellular ZBP1 and PLCgamma1 proteins. Conversely, decreasing the levels of cellular miR-222 by transfection with its antagonism increased the stability of the ZBP1 and PLCyl mRNAs and increased the levels of ZBP1 and PLCgamma1 proteins. Overexpression of miR-222 also inhibited cell migration over the wounded area, which was partially abolished by overexpressing ZBP1 and PLCgamma1.
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