Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

He Chang; Zhao Chen; Kumar AnilLee ChunsikChen MingquanHuang LijuanWang JingRen XiangrongJiang YidaChen WeiWang BinGao ZhiqinZhong ZhengHuang ZijingZhang FanHuang BingDing HaoJu RongTang ZhongshuLiu YizhiCao YihaiLi XuriLiu Xialin

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

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Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

机译：Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

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Blood vessel degeneration is critically involved in nearly all types of degenerative diseases. Therefore strategies to enhance blood vessel protection and survival are highly needed. In this study, using different animal models and cultured cells, we show that PDGF-CC is a potent vascular protective and survival factor. PDGF-CC deficiency by genetic deletion exacerbated blood vessel regression/degeneration in various animal models. Importantly, treatment with PDGF-CC protein not only increased the survival of retinal blood vessels in a model of oxygen-induced blood vessel regression but also markedly rescued retinal and blood vessel degeneration in a disease model of retinitis pigmentosa. Mechanistically, we revealed that heme oxygenase-1 (HMOX1) activity is critically required for the vascular protective/survival effect of PDGF-CC, because blockade of HMOX1 completely abolished the protective effect of PDGF-CC in vitro and in vivo. We further found that both PDGF receptors, PDGFR-beta and PDGFR-alpha, are required for the vasoprotective effect of PDGF-CC. Thus our data show that PDGF-CC plays a pivotal role in maintaining blood vessel survival and may be of therapeutic value in treating various types of degenerative diseases.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第41期|14806-14811|共6页
作者
He Chang; Zhao Chen; Kumar AnilLee ChunsikChen MingquanHuang LijuanWang JingRen XiangrongJiang YidaChen WeiWang BinGao ZhiqinZhong ZhengHuang ZijingZhang FanHuang BingDing HaoJu RongTang ZhongshuLiu YizhiCao YihaiLi XuriLiu Xialin;
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作者单位

Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China;

Nanjing Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Nanjing 210029, Jiangsu, Peoples R China;

Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, SwedenBinzhou Med Univ, Med Imaging Inst, Yantai 264003, Peoples R ChinaWeifang Med Univ, Dept Cell Biol, Weifang 261053, Peoples R ChinaUniv Manitoba, Dept Biochem & Med Genet, Winnipeg, MB R3E 3P5, Canada;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
PDGF-CC; vasoprotective effect; blood vessel regression; HMOX1; retinal degeneration;

Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

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