H_2S mediates O_2 sensing in the carotid body

Peng Y.-J.; Nanduri J.; Raghuraman G.Souvannakitti D.Gadalla M.M.Kumar G.K.Snyder S.H.Prabhakar N.R.

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H_2S mediates O_2 sensing in the carotid body

机译：H_2S mediates O_2 sensing in the carotid body

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Gaseous messengers, nitric oxide and carbon monoxide, have been implicated in O_2 sensing by the carotid body, a sensory organ that monitors arterial blood O_2 levels and stimulates breathing in response to hypoxia. We now show that hydrogen sulfide (H_2S) is a physiologic gasotransmitter of the carotid body, enhancing its sensory response to hypoxia. Glomus cells, the site of O_2 sensing in the carotid body, express cystathionine γ-lyase (CSE), an H_2S-generating enzyme, with hypoxia increasing H_2S generation in a stimulus-dependent manner. Mice with genetic deletion of CSE display severely impaired carotid body response and ventilatory stimulation to hypoxia, as well as a loss of hypoxia-evoked H_2S generation. Pharmacologic inhibition of CSE elicits a similar phenotype in mice and rats. Hypoxia-evoked H_2S generation in the carotid body seems to require interaction of CSE with hemeoxygenase-2, which generates carbon monoxide. CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第23期|10719-10724|共6页
作者
Peng Y.-J.; Nanduri J.; Raghuraman G.Souvannakitti D.Gadalla M.M.Kumar G.K.Snyder S.H.Prabhakar N.R.;
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作者单位

Center for Systems Biology for O2 Sensing, Department of Medicine, University of Chicago, IL 60637, United States;

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21205-2105, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Cystathionine γ-lyase; Hemeoxygenase-2; Hydrogen sulfide; Hypoxia;

H_2S mediates O_2 sensing in the carotid body

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