Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses

Nicole von Burg; Stéphane Chappaz; Anne BaerenwaldtEdit HorvathSomdeb Bose DasguptaDevika AshokJean PietersFabienne Tacchini-CottierAntonius RolinkHans Acha-OrbeaDaniela Finke

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Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses

机译：Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses

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Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokines, up-regulate surface MHC class II molecules, and express costimulatory molecules. ILC3s can take up latex beads, process protein antigen, and consequently prime CD4~+ T-cell responses in vitro. The cognate interaction of ILC3s and CD4~+ T cells leads to T-cell proliferation both in vitro and in vivo, whereas its disruption impairs specific T-cell and T-dependent B-cell responses in vivo. In addition, the ILC3-CD4~+ T-cell interaction is bidirectional and leads to the activation of ILC3s. Taken together, our data reveal a novel activation-dependent function of peripheral ILC3s in eliciting cognate CD4~+ T-cell immune responses.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第35期|12835-12840|共6页
作者
Nicole von Burg; Stéphane Chappaz; Anne BaerenwaldtEdit HorvathSomdeb Bose DasguptaDevika AshokJean PietersFabienne Tacchini-CottierAntonius RolinkHans Acha-OrbeaDaniela Finke;
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作者单位

Department of Biomedicine, University of Basel, 4058 Basel, Switzerland;

Biozentrum, University of Basel, 4056 Basel, Switzerland;

Department of Biochemistry and gWorld Health Organization Immunology Research and Training Centre, University of Lausanne, 1066 Epalinges, SwitzerlandDepartment of Biochemistry and Training Centre, University of Lausanne, 1066 Epalinges, Switzerland;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
T-cell-mediated; immune; responses;

Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses

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