Differential hERG ion channel activity of ultrasmall gold nanoparticles

Leifert A.; Pan Y.; Kinkeldey A.Schiefer F.Setzler J.Scheel O.Lichtenbeld H.Schmid G.Wenzel W.Jahnen-Dechent W.Simon U.

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Differential hERG ion channel activity of ultrasmall gold nanoparticles

机译：Differential hERG ion channel activity of ultrasmall gold nanoparticles

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Understanding the mechanism of toxicity of nanomaterials remains a challenge with respect to both mechanisms involved and product regulation. Here we show toxicity of ultrasmall gold nanoparticles (AuNPs). Depending on the ligand chemistry, 1.4-nm-diameter AuNPs failed electrophysiology-based safety testing using human embryonic kidney cell line 293 cells expressing human ether-á-go-go- Related gene (hERG), a Food and Drug Administration- established drug safety test. In patch-clamp experiments, phosphine-stabilized AuNPs irreversibly blocked hERG channels, whereas thiol-stabilized AuNPs of similar size had no effect in vitro, and neither particle blocked the channel in vivo. We conclude that safety regulations may need to be reevaluated and adapted to reflect the fact that the binding modality of surface functional groups becomes a relevant parameter for the design of nanoscale bioactive compounds.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第20期|8004-8009|共6页
作者
Leifert A.; Pan Y.; Kinkeldey A.Schiefer F.Setzler J.Scheel O.Lichtenbeld H.Schmid G.Wenzel W.Jahnen-Dechent W.Simon U.;
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作者单位

Institute of Inorganic Chemistry, Jülich Aachen Research Alliance-Fundamentals of Information Technology, Germany;

Helmholtz-Institute for Biomedical Engineering, Biointerface Laboratory, Rheinisch-Westf?lische Technische Hochschule Aachen University, 52074 Aachen, Germany;

Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, GermanyCytocentrics Bioscience GmbH, 18059 Rostock, GermanyHLConsulting, 6202 TC, Maastricht, NetherlandsInstitute of Inorganic Chemistry, University of Duisburg-Essen, 80639 Munich, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Complementarity; Gold cluster; Nanotoxicology; Shape;

Differential hERG ion channel activity of ultrasmall gold nanoparticles

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