Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses

Neher Richard A.; Bedford Trevor; Daniels Rodney S.Russell Colin A.Shraiman Boris I.

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Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses

机译：Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses

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Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and reinfect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA), and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies. Here, we show that antigenic differences measured through serological assay data are well described by a sum of antigenic changes along the path connecting viruses in a phylogenetic tree. This mapping onto the tree allows prediction of antigenicity from HA sequence data alone. The mapping can further be used to make predictions about the makeup of the future A(H3N2) seasonal influenza virus population, and we compare predictions between models with serological and sequence data. To make timely model output readily available, we developed a web browser-based application that visualizes antigenic data on a continuously updated phylogeny.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2016年第12期|E1701-E1709|共9页
作者
Neher Richard A.; Bedford Trevor; Daniels Rodney S.Russell Colin A.Shraiman Boris I.;
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作者单位

Max Planck Inst Dev Biol, Evolutionary Dynam & Biophys, D-72076 Tubingen, Germany;

Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA;

Francis Crick Inst, Worldwide Influenza Ctr, London NW7 1AA, EnglandUniv Cambridge, Dept Vet Med, Cambridge CB3 0ES, EnglandUniv Calif Santa Barbara, Kavli Inst Theoret Phys, Santa Barbara, CA 93106 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
evolution; antigenic distance; phylogenetic tree;

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses

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