Chemical sensing in mammalian host-bacterial commensal associations

Hughes D.T.; Terekhova D.A.; Liou L.Hovde C.J.Sahl J.W.Patankar A.V.Gonzalez J.E.Edrington T.S.Rasko D.A.Sperandio V.

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Chemical sensing in mammalian host-bacterial commensal associations

机译：Chemical sensing in mammalian host-bacterial commensal associations

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The mammalian gastrointestinal (GI) tract is colonized by a complex consortium of bacterial species. Bacteria engage in chemical signaling to coordinate population-wide behavior. However, it is unclear if chemical sensing plays a role in establishing mammalian host-bacterial commensal relationships. Enterohemorrhagic Escherichia coli (EHEC) is a deadly human pathogen but is a member of the GI flora in cattle, its main reservoir. EHEC harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria. Here,we show that SdiA is necessary for EHEC colonization of cattle and that AHLs are prominent within the bovine rumen but absent in other areas of the GI tract.We also assessed the rumen metagenome of heifers, and we show that it is dominated by Clostridia and/or Bacilli but also harbors Bacteroidetes.Of note, somemembers of the Bacteroidetes phyla have been previously reported to produce AHLs. SdiA-AHL chemical signaling aids EHEC in gauging these GI environments, and promotes adaptation to a commensal lifestyle.We show that chemical sensing in the mammalian GI tractdetermines the niche specificity for colonization by a commensal bacterium of its natural animal reservoir. Chemical sensing may be a general mechanism used by commensal bacteria to sense and adapt to their mammalian hosts. Additionally, because EHEC is largely prevalent in cattle herds, interference with SdiA-mediated cattle colonization is an exciting alternative to diminish contamination of meat products and cross-contamination of produce crops because of cattle shedding of this human pathogen.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第21期|9831-9836|共6页
作者
Hughes D.T.; Terekhova D.A.; Liou L.Hovde C.J.Sahl J.W.Patankar A.V.Gonzalez J.E.Edrington T.S.Rasko D.A.Sperandio V.;
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作者单位

Department of Amicrobiology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, United States;

Department of Microbiology, University of Idaho, Moscow, ID 83844, United States;

Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, United StatesDepartment of Molecular and Cell Biology, University of Texas, Dallas, TX 75083, United StatesAgricultural Research Services, US Department of Agriculture, College Station, TX 77845, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Bovine; Enterohemorrhagic Escherichia coli; Metagenomics; Rumen;

Chemical sensing in mammalian host-bacterial commensal associations

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