Dorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats

Kim E.J.; Horovitz O.; Pellman B.A.Tan L.M.Li Q.Richter-Levin G.Kim J.J.

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Dorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats

机译：Dorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats

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The periaqueductal gray (PAG) and amygdala are known to be important for defensive responses, and many contemporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropriate behavior (i.e., freezing or fleeing). However, empirical studies of this circuitry are inconsistent and warrant further examination. Hence, the present study investigated the functional relationship between the PAG and amygdala in two different settings, fear conditioning and naturalistic foraging, in rats. In fear conditioning, electrical stimulation of the dorsal PAG (dPAG) produced unconditional responses (URs) composed of brief activity bursts followed by freezing and 22-kHz ultrasonic vocalization. In contrast, stimulation of ventral PAG and the basolateral amygdalar complex (BLA) evoked freezing and/or ultrasonic vocalization. Whereas dPAG stimulation served as an effective unconditional stimulus for fear conditioning to tone and context conditional stimuli, neither ventral PAG nor BLA stimulation supported fear conditioning. The conditioning effect of dPAG, however, was abolished by inactivation of the BLA. In a foraging task, dPAG and BLA stimulation evoked only fleeing toward the nest. Amygdalar lesion/inactivation blocked the UR of dPAG stimulation, but dPAG lesions did not block the UR of BLA stimulation. Furthermore, in vivo recordings demonstrated that electrical priming of the dPAG can modulate plasticity of subiculum- BLA synapses, providing additional evidence that the amygdala is downstream of the dPAG. These results suggest that the dPAG conveys unconditional stimulus information to the BLA, which directs both innate and learned fear responses, and that brain stimulation-evoked behaviors are modulated by context.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第36期|14795-14800|共6页
作者
Kim E.J.; Horovitz O.; Pellman B.A.Tan L.M.Li Q.Richter-Levin G.Kim J.J.;
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作者单位

Department of Psychology, University of Washington, Seattle, WA 98195-1525, United States;

Psychology Department, University of Haifa, Mount Carmel, Haifa 3190501, Israel;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Fear circuitry; Learning and memory; Long-term depression; Long-term potentiation; Synaptic plasticity;

Dorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats

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