Probing the relative orientation of molecules bound to DNA through controlled interference using second-harmonic generation

Doughty B.; Rao Y.; Kazer S.W.Kwok S.J.J.Turro N.J.Eisenthal K.B.

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Probing the relative orientation of molecules bound to DNA through controlled interference using second-harmonic generation

机译：Probing the relative orientation of molecules bound to DNA through controlled interference using second-harmonic generation

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摘要

A method is described in which the interference of radiated secondharmonic electric fields generated by a pair of oriented molecules intercalated into double-stranded DNA is controlled and measured. The results show that the relative molecular orientation of the two molecules significantly changes the magnitude of the observed second-harmonic generation intensity, which is described by a simple model that accounts for the interferences of the radiated fields. The technique presented shows promise for future experiments investigating structural changes induced bythe formation of a DNA-biomolecule complex.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第15期|5756-5758|共3页
作者
Doughty B.; Rao Y.; Kazer S.W.Kwok S.J.J.Turro N.J.Eisenthal K.B.;
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作者单位

Department of Chemistry, Columbia University, New York, NY 10027, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Alignment; Daunorubicin; Equilibrium binding; Nonlinear spectroscopy; Phase;

Probing the relative orientation of molecules bound to DNA through controlled interference using second-harmonic generation

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