Positive and negative feedback loops in the p53 and mRNA 3' processing pathways

Devany E.; Zhang X.; Park J.Y.Tian B.Kleiman F.E.

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Positive and negative feedback loops in the p53 and mRNA 3' processing pathways

机译：Positive and negative feedback loops in the p53 and mRNA 3' processing pathways

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Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the p53 mRNA. Here, we provide evidence of a feedback loop between p53 and the poly(A)-specific ribonuclease (PARN), in which PARN deadenylase keeps p53 levels low in nonstress conditions by destabilizing p53 mRNA, and the UV-induced increase in p53 activates PARN deadenylase, regulating gene expression during DNA damage response in a transactivation-independent manner. This model is innovative because it provides insights into p53 function and the mechanisms behind the regulation of mRNA 3' end processing in different cellular conditions.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第9期|3351-3356|共6页
作者
Devany E.; Zhang X.; Park J.Y.Tian B.Kleiman F.E.;
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作者单位

Chemistry Department, Hunter College and Graduate Center, City University of New York, New York, NY 10065, United States;

Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Deadenylation; Gene expression control; MRNA 3' processing; MRNA steady state levels;

Positive and negative feedback loops in the p53 and mRNA 3' processing pathways

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