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外文期刊>european journal of neuroscience
>Retrograde Axonal Transport of the α‐Subunit of the GTP‐binding Protein Gzin Mouse Sciatic Nerve: a Potential Pathway for Signal Transduction In Neurons
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Retrograde Axonal Transport of the α‐Subunit of the GTP‐binding Protein Gzin Mouse Sciatic Nerve: a Potential Pathway for Signal Transduction In Neurons
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机译：Retrograde Axonal Transport of the α‐Subunit of the GTP‐binding Protein Gzin Mouse Sciatic Nerve: a Potential Pathway for Signal Transduction In Neurons
AbstractWe have utilized antibodies against the α subunit of Gzin fluorescence immunohistochemistry to determine whether this GTP‐binding protein can translocate along nerves by intra‐axonal transport. After ligation of the mouse sciatic nerve we found an increase in Gz‐like immunoreactivity on the proximal and distal side with time, suggesting that the α subunit undergoes orthograde axonal transport and also returns to the cell body by retrograde axonal transport in the sciatic nerve. Unlike the retrograde transport of Giα, shown in a previous study to be present in most sciatic axons, Gzαonly accumulated in a subpopulation of axons, suggesting that different G‐proteins could convey information specific to neuronal subtypes. These results support our proposal that Gzmay play a second messenger role in communicating information from the terminals back to cell bodies. Giαand Gzαmay be representative of relatively stable signalling molecules by which the signal from some neurotrophic molecules can be translocated from the neuronal periphery to the cell body without the need for the retrograde transport of the neurotrophic
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