Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers

Yi-Wei Lou; Pao-Yuan Wang; Shih-Chi YehPo-Kai ChuangShiou-Ting LiChung-Yi WuKay-Hooi KhooMichael HsiaoT_sui-Ling HsuChi-Huey Wong

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Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers

机译：Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers

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Glioblastoma multiforme (GBM), the grade IV astrocytoma, is the most common and aggressive brain tumor in adults. Despite advances in medical management, the survival rate of GBM patients remains poor, suggesting that identification of GBM-specific targets for therapeutic development is urgently needed. Analysis of several glycan antigens on GBM cell lines revealed that eight of 11 GBM cell lines are positive for stage-specific embryonic antigen-4 (SSEA-4), and immunohistochemical staining confirmed that 38/55 (69) of human GBM specimens, but not normal brain tissue, were SSEA-4~+ and correlated with high-grade astrocytoma. In addition, an SSEA-4–specific mAb was found to induce complement-dependent cytotoxicity against SSEA-4~(hi) GBM cell lines in vitro and suppressed GBM tumor growth in mice. Because SSEA-4 is expressed on GBM and many other types of cancers, but not on normal cells, it could be a target for development of therapeutic antibodies and vaccines.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第7期|2482-2487|共6页
作者
Yi-Wei Lou; Pao-Yuan Wang; Shih-Chi YehPo-Kai ChuangShiou-Ting LiChung-Yi WuKay-Hooi KhooMichael HsiaoT_sui-Ling HsuChi-Huey Wong;
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作者单位

Genomics Research Center, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan;

Genomics Research Center, Academia Sinica, Taipei 115, Taiwan;

Institute of Biological Chemistry, Academia Sinica, Taipei 115, TaiwanInstitute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
glycosphingolipids; Globo H; SSEA-3; gangliosides; targeted therapy;

Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers

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