Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances theta oscillations in the hippocampus

Marie Vandecasteele; Viktor Varga; Antal BerényiEdit PappPéter BarthóLaurent VenanceTamás F. FreundGy?rgy Buzsáki

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Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances theta oscillations in the hippocampus

机译：Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances theta oscillations in the hippocampus

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Theta oscillations in the limbic system depend on the integrity of the medial septum. The different populations of medial septal neurons (cholinergic and GABAergic) are assumed to affect different aspects of theta oscillations. Using optogenetic stimulation of cholinergic neurons in ChAT-Cre mice, we investigated their effects on hippocampal local field potentials in both anesthetized and behaving mice. Cholinergic stimulation completely blocked sharp wave ripples and strongly suppressed the power of both slow oscillations (0.5-2 Hz in anesthetized, 0.5-4 Hz in behaving animals) and supratheta (6-10 Hz in anesthetized, 10-25 Hz in behaving animals) bands. The same stimulation robustly increased both the power and coherence of theta oscillations (2-6 Hz) in urethane-anesthetized mice. In behaving mice, cholinergic stimulation was less effective in the theta (4-10 Hz) band yet it also increased the ratio of theta/slow oscillation and theta coherence. The effects on gamma oscillations largely mirrored those of theta. These findings show that medial septal cholinergic activation can both enhance theta rhythm and suppress peri-theta frequency bands, allowing theta oscillations to dominate.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第37期|13535-13540|共6页
作者
Marie Vandecasteele; Viktor Varga; Antal BerényiEdit PappPéter BarthóLaurent VenanceTamás F. FreundGy?rgy Buzsáki;
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作者单位

Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102;

Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083, Budapest, Hungary;

Center for Interdisciplinary Research in Biology, Institut National de la Santé et de la Recherche Médicale U1050, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Collège de France, F-75005 Paris, France;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
acetylcholine; channelrhodopsin-2; silicon probe; in vivo electrophysiology;

Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances theta oscillations in the hippocampus

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