GAL_3 receptor KO mice exhibit an anxietylike phenotype

Susanne M. Brunner; Aitak Farzi; Felix LockerBarbara S. HolubMeinrad DrexelFlorian ReichmannAndreas A. LangJohannes A. MayrJorge J. VilchesXavier NavarroRoland LangGünther SperkPeter HolzerBarbara Kofler

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GAL_3 receptor KO mice exhibit an anxietylike phenotype

机译：GAL_3 receptor KO mice exhibit an anxietylike phenotype

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The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems. It is a modulator of various physiological and pathological processes, and it mediates its effects via three G protein-coupled receptors (GAL1-3 receptors). A role for GAL as a modulator of mood and anxiety was suggested, because GAL and its receptors are highly expressed in limbic brain structures of rodents. In recent years, numerous studies of animal models have suggested an involvement of GAL and GAL1 and GAL2 receptors in anxiety- and depression-related behavior. However, to date, there is sparse literature implicating GAL_3 receptors in behavioral functions. Therefore, we studied the behavior of GAL_3 receptor-deficient (GAL_3-KO) mice to elucidate whether GAL_3 receptors are involved in mediating behavior-associated actions of GAL. The GAL_3-KO mouse line exhibited normal breeding and physical development. In addition to behavioral tests, phenotypic characterization included analysis of hematology, amino acid profiles, metabolism, and sudomotor function. In contrast to WT littermates, male GAL_3-KO mice exhibited an anxietylike phenotype in the elevated plus maze, open field, and light/ dark box tests, and they were less socially affiliated than WT animals to a stranger mouse in a social interaction test. In conclusion, our data suggest involvement of GAL_3 receptors in GAL-mediated effects on mood, anxiety, and behavior, making it a possible target for alternative treatment strategies for mood disorders.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第19期|7138-7148|共11页
作者
Susanne M. Brunner; Aitak Farzi; Felix LockerBarbara S. HolubMeinrad DrexelFlorian ReichmannAndreas A. LangJohannes A. MayrJorge J. VilchesXavier NavarroRoland LangGünther SperkPeter HolzerBarbara Kofler;
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作者单位

Laura Bassi Centre of Expertise-Therapeutic Application of Neuropeptides (THERAPEP), Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University;

Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria;

Department of Pharmacology, Medical University Innsbruck, 6020 Innsbruck, AustriaDepartment of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainDepartment of Dermatology, Paracelsus Medical University, 5020 Salzburg, Austria;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
receptor; exhibit; anxietylike;

GAL_3 receptor KO mice exhibit an anxietylike phenotype

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