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首页> 外文期刊>International Journal of Cell Biology >Selective Autophagy in Drosophila
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Selective Autophagy in Drosophila

机译：果蝇中的选择性自噬

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Autophagy is an evolutionarily conserved process of cellular self-eating and is a major pathway for degradation of cytoplasmic material by the lysosomal machinery. Autophagy functions as a cellular response in nutrient starvation, but it is also associated with the removal of protein aggregates and damaged organelles and therefore plays an important role in the quality control of proteins and organelles. Although it was initially believed that autophagy occurs randomly in the cell, during the last years, there is growing evidence that sequestration and degradation of cytoplasmic material by autophagy can be selective. Given the important role of autophagy and selective autophagy in several disease-related processes such as neurodegeneration, infections, and tumorigenesis, it is important to understand the molecular mechanisms of selective autophagy, especially at the organismal level. Drosophila is an excellent genetically modifiable model organism exhibiting high conservation in the autophagic machinery. However, the regulation and mechanisms of selective autophagy in Drosophila have been largely unexplored. In this paper, I will present an overview of the current knowledge about selective autophagy in Drosophila.
机译：自噬是细胞自我进食的进化保守过程，是溶酶体机制降解细胞质物质的主要途径。自噬在营养缺乏时起细胞反应的作用，但也与蛋白质聚集体和受损细胞器的去除有关，因此在蛋白质和细胞器的质量控制中起着重要作用。尽管最初认为自噬是随机发生在细胞中的，但是在最近几年中，越来越多的证据表明，通过自噬可以隔离和降解细胞质物质。鉴于自噬和选择性自噬在几种与疾病相关的过程中的重要作用，例如神经退行性疾病，感染和肿瘤发生，因此了解选择性自噬的分子机制，特别是在机体水平上的分子机制非常重要。果蝇是一种优秀的可遗传修饰的模式生物，在自噬机制中表现出很高的保守性。但是，果蝇中选择性自噬的调控和机制尚未得到充分的探索。在本文中，我将概述果蝇中选择性自噬的最新知识。

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