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外文期刊>british journal of haematology
>Excretion of Endogenous Non‐haem Iron by the Gastrointestinal Tract in Human Subjects and its Influence on the Size of Body Store of Iron with Particular Reference to Coeliac Disease
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Excretion of Endogenous Non‐haem Iron by the Gastrointestinal Tract in Human Subjects and its Influence on the Size of Body Store of Iron with Particular Reference to Coeliac Disease
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机译：Excretion of Endogenous Non‐haem Iron by the Gastrointestinal Tract in Human Subjects and its Influence on the Size of Body Store of Iron with Particular Reference to Coeliac Disease
The present study demonstrates that there is continuous loss of endogenous non‐haem iron by the gastrointestinal tract in man, and underlines its importance in patients with coeliac disease and in those with iron overload. The findings suggest that this loss occurs mainly as a result of desquamation of villous epithelium. The faecal loss of endogenous non‐haem iron is markedly increased in patients with coeliac disease in whom the cell turnover of the small intestinal mucosa is increased and it seems that it could be mainly responsible for the causation of iron deficiency amongst a considerable number of these patients.In subjects with normal mucosal structure of the small intestine this loss increases progressively with iron load at high levels of labile iron store and thus reduces the total iron store in the b
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