Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

Wataru Ise; Takeshi Inoue; James B. McLachlanKohei KometaniMasato KuboTakaharu OkadaTomohiro Kurosaki

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

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Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

机译：Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

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In primary humoral responses, B-cell lymphoma 6 (Bcl6) is a master regulator of follicular helper T (T_(FH)) cell differentiation; however, its activation mechanisms and role in memory responses remain unclear. Here we demonstrate that survival of CXCR5~+ TFH memory cells, and thus subsequent recall antibody response, require Bcl6 expression. Furthermore, we show that, upon rechallenge with soluble antigen Bcl6 in memory T_(FH) cells is rapidly induced in a dendritic cell-independent manner and that peptide:class II complexes (pMHC) on cognate memory B cells significantly contribute to this induction. Given the previous evidence that antigen-specific B cells residing in the follicles acquire antigens within minutes of injection, our results suggest that memory B cells present antigens to the cognate T_(FH) memory cells, thereby contributing to rapid Bcl6 reexpression and differentiation of the T_(FH) memory cells during humoral memory responses.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第32期|11792-11797|共6页
作者
Wataru Ise; Takeshi Inoue; James B. McLachlanKohei KometaniMasato KuboTakaharu OkadaTomohiro Kurosaki;
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作者单位

Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan;

Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112;

Laboratory for Lymphocyte Differentiation RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, JapanLaboratory for Cytokine Regulation RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, JapanLaboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
immunological memory; antibody production;

Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

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