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机译:A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland;
Chemical and Physical Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas CIB-CSIC, 28040 Madrid, Spain;
Swiss Light Source, Paul Scherrer Institut, 5232 Villigen PSI, SwitzerlandPharmaMar S.A., 28770 Madrid, SpainDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zürich, 8093 Zürich, Switzerland;
drug mechanism; microtubule-targeting agents; X-ray crystallography;