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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Fabrication of nonwoven fabrics consisting of gelatin nanofibers cross-linked by glutaraldehyde or N-acetyl-D-glucosamine by aqueous method
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Fabrication of nonwoven fabrics consisting of gelatin nanofibers cross-linked by glutaraldehyde or N-acetyl-D-glucosamine by aqueous method

机译：用水法制备由戊二醛或N-乙酰基-D-葡萄糖胺交联的明胶纳米纤维组成的无纺布

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Since gelatin (Gel) undergoes a sol-gel transition, a novel dry-spinning procedure for Gel was used. Here, nonwoven fabrics of Gel were electrospun by applying the principles of dry spinning. The diameter of the fibers and the viscosity and flow rate of the solution were directly dependent on the concentration of Gel. Nonwoven fabrics spun with a 25% (w/w) Gel concentration only exhibited a nanoscale fiber diameter. In order to improve the properties of the nonwoven fabrics, they were cross-linked with glutaraldehyde (GTA) vapor after spinning or by the addition of N-acetyl-D-glucosamine (GlcNAc) to the Gel solution prior to spinning followed by heating these fibers. The developed nonwoven fibers were characterized using SEM, rheometry, FTIR, TGA, and mechanical tensile testing. The nonwoven fabrics cross-linked by the GTA vapor exhibited improved mechanical properties compared to those without cross-linking or with GlcNAc cross-linking. The swelling and water uptake ability resulted in no morphological changes in the fibers with GTA cross-linking. The TGA thermogram confirmed no phase change in the composite structure. Further, in vitro cytocompatibility studies using human mesenchymal stem cells showed the compatible nature of the developed nonwoven fibers. Our studies showed that these nonwoven fibers could be useful in medical care. (C) 2016 Elsevier B.V. All rights reserved.
机译：由于明胶（Gel）经历了溶胶-凝胶转变，因此使用了一种新颖的凝胶干法纺丝工艺。在此，通过应用干纺原理将凝胶无纺布进行电纺。纤维的直径以及溶液的粘度和流速直接取决于凝胶的浓度。以25％（w / w）的凝胶浓度纺制的非织造布仅表现出纳米级的纤维直径。为了改善非织造织物的性能，在纺丝后或通过在纺丝前向凝胶溶液中添加N-乙酰基-D-葡萄糖胺（GlcNAc）使其与戊二醛（GTA）蒸汽交联，然后对其进行加热。纤维。使用SEM，流变仪，FTIR，TGA和机械拉伸测试对已开发的非织造纤维进行了表征。与没有交联或具有GlcNAc交联的那些相比，通过GTA蒸气交联的非织造织物表现出改善的机械性能。溶胀和吸水能力导致具有GTA交联的纤维没有形态变化。 TGA热分析图证实了复合结构中没有相变。此外，使用人间充质干细胞进行的体外细胞相容性研究表明，已开发的非织造纤维具有相容性。我们的研究表明，这些非织造纤维可用于医疗保健。 （C）2016 Elsevier B.V.保留所有权利。

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