Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

Jenner L.; Starosta A.L.; Terry D.S.Mikolajka A.Filonava L.Yusupov M.Blanchard S.C.Wilson D.N.Yusupova G.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

【24h】

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

机译：Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Here we present an X-ray crystallography structure of the clinically relevant tigecycline antibiotic bound to the 70S ribosome. Our structural and biochemical analysis indicate that the enhanced potency of tigecycline results from a stacking interaction with nucleobase C1054 within the decoding site of the ribosome. Singlemolecule fluorescence resonance energy transfer studies reveal that, during decoding, tigecycline inhibits the initial codon recognition step of tRNA accommodation and prevents rescue by the tetracycline-resistance protein TetM.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第10期|3812-3816|共5页
作者
Jenner L.; Starosta A.L.; Terry D.S.Mikolajka A.Filonava L.Yusupov M.Blanchard S.C.Wilson D.N.Yusupova G.;
展开▼
作者单位

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7104, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France;

Department for Biochemistry, Gene Center, University of Munich, 81377 Munich, Germany;

Department of Physiology and Biophysics, Weill Medical College, Cornell University, New York, NY 10065, United States;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

摘要

著录项

相关主题

期刊订阅