Myocardial aging as a T-cell-mediated phenomenon

Ramos Gustavo Campos; van den Berg Anne; Nunes-Silva VniaWeirather JohannesPeters LauraBurkard MatthiasFriedrich MikePinnecker JuergenAbesser MarcoHeinze Katrin G.Schuh KaiBeyersdorf NiklasKerkau ThomasDemengeot JocelyneFrantz StefanHofmann Ulrich

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Myocardial aging as a T-cell-mediated phenomenon

机译：Myocardial aging as a T-cell-mediated phenomenon

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In recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies. Aging is an important risk factor for heart diseases, and it also has impact on the immune system. Thus, we sought to determine whether immunological activity would influence myocardial structure and function in elderly mice. Morphological, functional, and molecular analyses revealed that the age-related myocardial impairment occurs in parallel with shifts in the composition of tissue-resident leukocytes and with an accumulation of activated CD4+ Foxp3(-)(forkhead box P3) IFN-gamma(+) T cells in the heart-draining lymph nodes. A comprehensive characterization of different aged immune-deficient mouse strains revealed that T cells significantly contribute to age-related myocardial inflammation and functional decline. Upon adoptive cell transfer, the T cells isolated from the mediastinal lymph node (med-LN) of aged animals exhibited increased cardiotropism, compared with cells purified from young donors or from other irrelevant sites. Nevertheless, these cells caused rather mild effects on cardiac functionality, indicating that myocardial aging might stem from a combination of intrinsic and extrinsic (immunological) factors. Taken together, the data herein presented indicate that heart-directed immune responses may spontaneously arise in the elderly, even in the absence of a clear tissue damage or concomitant infection. These observations might shed new light on the emerging role of T cells in myocardial diseases, which primarily affect the elderly population.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2017年第12期|E2420-E2429|共10页
作者
Ramos Gustavo Campos; van den Berg Anne; Nunes-Silva VniaWeirather JohannesPeters LauraBurkard MatthiasFriedrich MikePinnecker JuergenAbesser MarcoHeinze Katrin G.Schuh KaiBeyersdorf NiklasKerkau ThomasDemengeot JocelyneFrantz StefanHofmann Ulrich;
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作者单位

Univ Clin Halle, Dept Internal Med 3, D-06120 Halle, Germany;

Inst Gulbenkian Cincia, PL-2781901 Oeiras, Portugal;

Univ Clin Wuerzburg, Comprehens Heart Failure Ctr, D-97078 Wurzburg, GermanyUniv Wurzburg, Rudolf Virchow Ctr Expt Biomed, D-97080 Wurzburg, GermanyUniv Wurzburg, Inst Physiol 1, D-97070 Wurzburg, GermanyUniv Wurzburg, Inst Virol & Immunobiol, D-97078 Wurzburg, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
myocardial; aging; T cells; inflammation; inflammaging;

Myocardial aging as a T-cell-mediated phenomenon

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