Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface

Springer A.; Hagen V.; Cherepanov D.A.Antonenko Y.N.Pohl P.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface

【24h】

Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface

机译：Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Proton diffusion along membrane surfaces is thought to be essential for many cellular processes such as energy transduction. Commonly, it is treated as a succession of jumps between membraneanchored proton-binding sites. Our experiments provide evidence for an alternative model. We released membrane-bound caged protons by UV flashes and monitored their arrival at distant sites by fluorescence measurements. The kinetics of the arrival is probed as a function of distance for different membranes and for different water isotopes. We found that proton diffusion along the membrane is fast even in the absence of ionizable groups in the membrane, and it decreases strongly in D_2O as compared to H2O. We conclude that the fast proton transport along the membrane is dominated by diffusion via interfacial water, and not via ionizable lipid moieties.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2011年第35期|14461-14466|共6页
作者
Springer A.; Hagen V.; Cherepanov D.A.Antonenko Y.N.Pohl P.;
展开▼
作者单位

Institut für Biophysik, Johannes Kepler Universit?t, Altenberger Strasse 69, 4040 Linz, Germany;

Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany;

Frumkin Institute of Physical Chemistry and Electrochemistry, Moscow, Russian FederationBelozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Chemiosmotic theory; Fluorimetry; Planar bilayer; Proton-collecting antenna;

Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface

摘要

著录项

相关主题

期刊订阅