Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia

Cha Joo Young; Wee Jungwon; Jung JooyoungJang YongwooLee ByeongjunHong Gyu-SangChang Beom ChulChoi Yoon-LaShin Young KeeMin Hye-YoungLee Ho-YoungNa Tae-YoungLee Mi-OckOh Uhtaek

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Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia

机译：Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia

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Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate, causing lower urinary tract symptoms in elderly men worldwide. However, the molecular mechanism underlying the pathogenesis of BPH is unclear. Anoctamin1 (ANO1) encodes a Ca2+-activated chloride channel (CaCC) that mediates various physiological functions. Here, we demonstrate that it is essential for testosterone-induced BPH. ANO1 was highly amplified in dihydrotestosterone (DHT)-treated prostate epithelial cells, whereas the selective knockdown of ANO1 inhibited DHT-induced cell proliferation. Three androgen-response elements were found in the ANO1 promoter region, which is relevant for the DHT-dependent induction of ANO1. Administration of the ANO1 blocker or Ano1 small interfering RNA, inhibited prostate enlargement and reduced histological abnormalities in vivo. We therefore concluded that ANO1 is essential for the development of prostate hyperplasia and is a potential target for the treatment of BPH.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2015年第31期|9722-9727|共6页
作者
Cha Joo Young; Wee Jungwon; Jung JooyoungJang YongwooLee ByeongjunHong Gyu-SangChang Beom ChulChoi Yoon-LaShin Young KeeMin Hye-YoungLee Ho-YoungNa Tae-YoungLee Mi-OckOh Uhtaek;
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作者单位

Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, Grad Sch Convergence Sci & Technol, Seoul 151742, South Korea;

Seoul Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Seoul 151742, South Korea;

Seoul Natl Univ, Sensory Res Ctr, CRI, Coll Pharm, Seoul 151742, South KoreaJW Pharmaceut Co, Drug Discovery Ctr, Seoul 137864, South KoreaSungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul 135710, South Korea;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
prostate; hyperplasia; anoctamin 1; testosterone; proliferation;

Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia

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