Synthetic biotinylated tetra beta(1--5) galactofuranoside for in vitro aspergillosis diagnosis.

Cattiaux L; Sendid B; Collot MMachez EPoulain DMallet JM

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Synthetic biotinylated tetra beta(1--5) galactofuranoside for in vitro aspergillosis diagnosis.

机译：Synthetic biotinylated tetra beta(1--5) galactofuranoside for in vitro aspergillosis diagnosis.

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The synthesis of a tetra beta(1-->5) galactofuranoside was achieved using a thioglycoside donor with a methyl tert-butyl phenyl thio leaving group. This tetrasaccharide was conjugated to biotin and validated as antigen with the monoclonal antibody used for clinical detection of Aspergillus fumigatus galactomannan on streptavidin-coated microplates. Then we have shown its ability to detect antibodies associated with A. fumigatus induced disease by using sera from patients with Allergic broncho-pulmonary aspergillosis (ABPA) and correlated the results of antibody detection with those gained with a commercially available diagnostic test.

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来源
《Bioorganic and medicinal chemistry》 |2011年第1期|547-555|共9页
作者
Cattiaux L; Sendid B; Collot MMachez EPoulain DMallet JM;
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UPMC-ENS-CNRS, Laboratoire de BioMolecules, UMR 7203, Federation de Chimie Moleculaire FR 2769, Departement de Chimie, Ecole Normale Superieure, 24 rue Lhomond, 75005 Paris, France.;

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正文语种英语
中图分类药学;
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Synthetic biotinylated tetra beta(1--5) galactofuranoside for in vitro aspergillosis diagnosis.

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