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首页> 外文期刊>International Journal of Cancer =: Journal International du Cancer >Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis.
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Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis.

机译：吸烟与结直肠癌的发病率和死亡率：系统评价和荟萃分析。

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The association between cigarette smoking and colorectal cancer (CRC) has been controversial. To synthesize the available data, we conducted a comprehensive meta-analysis of all prospective studies. A total of 36 studies were included in our meta-analysis. We examined the association between smoking and CRC, colon cancer and rectal cancer in terms of incidence and mortality. Separate analyses were conducted for smoking status, daily cigarette consumption, duration, pack-years and age of initiation. Relative to nonsmokers, current and former smokers had a significantly increased risk of CRC incidence and mortality, respectively. When CRC data were combined with colon/rectal cancer data, current smokers had a significantly increased risk of CRC incidence. All 4 dose-response variables examined-daily cigarette consumption (RR = 1.38 for an increase of 40 cigarettes/day), duration (RR = 1.20 for an increase of 40 years of duration), pack-years (RR = 1.51 for an increase of 60 pack-years) and age of initiation (RR = 0.96 for a delay of 10 years in smoking initiation)-were significantly associated with CRC incidence (all p-values < 0.0001). The relationship between duration of smoking and rectal cancer incidence was also significant. Among the subset of studies that distinguished cancer by site, a higher risk was seen for rectal cancer than for colon cancer for all analyses. Among prospective studies, a consistent association exists between smoking and CRC. The association is stronger for rectal cancer than for colon cancer in the subset of studies that differentiated cancer by site.
机译：吸烟与结直肠癌（CRC）之间的关联一直存在争议。为了综合可用数据，我们对所有前瞻性研究进行了全面的荟萃分析。我们的荟萃分析共包括36项研究。我们从发病率和死亡率方面研究了吸烟与CRC，结肠癌和直肠癌之间的关系。对吸烟状况，每日吸烟量，持续时间，包装年数和起始年龄进行了单独的分析。相对于不吸烟者，现吸烟者和前吸烟者的CRC发病率和死亡率分别显着增加。当CRC数据与结肠/直肠癌数据结合使用时，当前吸烟者的CRC发生风险显着增加。检查所有4种剂量反应变量，即每天的卷烟消费量（每天增加40支卷烟，RR = 1.38），持续时间（增加40年的持续时间，RR = 1.20），包装年（增加时的RR = 1.51） （60包年）的吸烟年龄和开始吸烟的年龄（吸烟开始延迟10年，RR = 0.96）与CRC发生率显着相关（所有p值<0.0001）。吸烟时间与直肠癌发生率之间的关系也很重要。在按部位区分癌症的研究子集中，在所有分析中，直肠癌的风险均高于结肠癌。在前瞻性研究中，吸烟与CRC之间存在一致的关联。在按部位区分癌症的研究子集中，直肠癌的关联性强于结肠癌。

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