BMP signaling is required for the generation of primordial germ cells in an insect

Seth Donoughe; Taro Nakamura; Ben Ewen-CampenDelbert A. Green IILory HendersonCassandra G. Extavour

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BMP signaling is required for the generation of primordial germ cells in an insect

机译：BMP signaling is required for the generation of primordial germ cells in an insect

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Two modes of germ cell formation are known in animals. Specification through maternally inherited germ plasm occurs in many well-characterized model organisms, but most animals lack germ plasm by morphological and functional criteria. The only known alternativemechanism is induction, experimentally described only in mice, which specify germ cells through bone morphogenetic protein (BMP) signal-mediated induction of a subpopulation of mesodermal cells. Until this report, no experimental evidence of an inductive germ cell signal for specification has been available outside of vertebrates. Here we provide functional genetic experimental evidence consistent with a role for BMP signaling in germ cell formation in a basally branching insect. We show that primordial germ cells of the cricket Gryllus bimaculatus transduce BMP signals and require BMP pathway activity for their formation. Moreover, increased BMP activity leads to ectopic and supernumerary germ cells. Given the commonality of BMP signaling in mouse and cricket germ cell induction, we suggest that BMP-based germ cell formation may be a shared ancestral mechanism in animals.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第11期|4133-4138|共6页
作者
Seth Donoughe; Taro Nakamura; Ben Ewen-CampenDelbert A. Green IILory HendersonCassandra G. Extavour;
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作者单位

Departments of Organismic and Cellular Biology, Harvard University, Cambridge, MA 02138;

Departments of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
signaling; generation; germ;

BMP signaling is required for the generation of primordial germ cells in an insect

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