Functional conservation despite structural divergence in ligand-responsive RNA switches

Boerneke Mark A.; Dibrov Sergey M.; Gu JingWyles David L.Hermann Thomas

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Functional conservation despite structural divergence in ligand-responsive RNA switches

机译：Functional conservation despite structural divergence in ligand-responsive RNA switches

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An internal ribosome entry site (IRES) initiates protein synthesis in RNA viruses, including the hepatitis C virus (HCV). We have discovered ligand-responsive conformational switches in viral IRES elements. Modular RNA motifs of greatly distinct sequence and local secondary structure have been found to serve as functionally conserved switches involved in viral IRES-driven translation and may be captured by identical cognate ligands. The RNA motifs described here constitute a new paradigm for ligand-captured switches that differ from metabolite-sensing riboswitches with regard to their small size, as well as the intrinsic stability and structural definition of the constitutive conformational states. These viral RNA modules represent the simplest form of ligand-responsive mechanical switches in nucleic acids.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第45期|15952-15957|共6页
作者
Boerneke Mark A.; Dibrov Sergey M.; Gu JingWyles David L.Hermann Thomas;
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作者单位

Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92093 USA;

Univ Calif San Diego, Ctr Drug Discovery Innovat, La Jolla, CA 92093 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
IRES elements; translation regulation; RNA viruses; hepatitis C virus;

Functional conservation despite structural divergence in ligand-responsive RNA switches

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