Atomic structure and hierarchical assembly of a cross-β amyloid fibril

Fitzpatrick A.W.P.; Debelouchina G.T.; Bayro M.J.Clare D.K.Caporini M.A.Bajaj V.S.Jaroniec C.P.Wang L.Ladizhansky V.Müller S.A.MacPhee C.E.Waudby C.A.Mott H.R.De Simone A.Knowles T.P.J.Saibil H.R.Vendruscolo M.Orlova E.V.Griffin R.G.Dobson C.M.

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Atomic structure and hierarchical assembly of a cross-β amyloid fibril

机译：Atomic structure and hierarchical assembly of a cross-β amyloid fibril

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The cross-β amyloid form of peptides and proteins represents an archetypal and widely accessible structure consisting of ordered arrays of β-sheet filaments. These complex aggregates have remarkable chemical and physical properties, and the conversion of normally soluble functional forms of proteins into amyloid structures is linked to many debilitating human diseases, including several common forms of age-related dementia. Despite their importance, however, cross-β amyloid fibrils have proved to be recalcitrant to detailed structural analysis. By combining structural constraints from a series of experimental techniques spanning five orders of magnitude in length scale-including magic angle spinning nuclear magnetic resonance spectroscopy, X-ray fiber diffraction, cryoelectron microscopy, scanning transmission electron microscopy, and atomic force microscopy-we report the atomic-resolution (0.5 ?) structures of three amyloid polymorphs formed by an 11-residue peptide. These structures reveal the details of the packing interactions by which the constituent β-strands are assembled hierarchically into protofilaments, filaments, and mature fibrils.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第14期|5468-5473|共6页
作者
Fitzpatrick A.W.P.; Debelouchina G.T.; Bayro M.J.Clare D.K.Caporini M.A.Bajaj V.S.Jaroniec C.P.Wang L.Ladizhansky V.Müller S.A.MacPhee C.E.Waudby C.A.Mott H.R.De Simone A.Knowles T.P.J.Saibil H.R.Vendruscolo M.Orlova E.V.Griffin R.G.Dobson C.M.;
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作者单位

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

Francis Bitter Magnet Laboratory, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States;

Institute of Structural and Molecular Biology, Birkbeck College, London WC1E 7HX, United KingdomMaurice E. Müller Institute, Biozentrum, CH-4056 Basel, SwitzerlandSchool of Physics, University of Edinburgh, Edinburgh EH9 3JZ, United KingdomDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种英语
中图分类自然科学总论;
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Atomic structure and hierarchical assembly of a cross-β amyloid fibril

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