Strategies to alleviate original antigenic sin responses to influenza viruses

Kim J.H.; Davis W.G.; Sambhara S.Jacob J.

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Strategies to alleviate original antigenic sin responses to influenza viruses

机译：Strategies to alleviate original antigenic sin responses to influenza viruses

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Original antigenic sin is a phenomenon wherein sequential exposure to closely related influenza virus variants reduces antibody (Ab) response to novel antigenic determinants in the second strain and, consequently, impairs the development of immune memory. This could pose a risk to the development of immune memory in persons previously infected with or vaccinated against influenza. Here, we explored strategies to overcome original antigenic sin responses in mice sequentially exposed to two closely related hemagglutinin 1 neuraminidase 1 (H1N1) influenza strains A/PR/8/ 34 and A/FM/1/47. We found that dendritic cell-activating adjuvants Bordetella pertussis toxin (PT) or CpG ODN or a squalenebased oil-in-water nanoemulsion (NE), upon administration during the second viral exposure, completely protected mice from a lethal challenge and enhanced neutralizing-Ab titers against the second virus. Interestingly, PT and NE adjuvants when administered during the first immunization even prevented original antigenic sin in subsequent immunization without any adjuvants. As an alternative to using adjuvants, we also found that repeated immunization with the second viral strain relieved the effects of original antigenic sin. Taken together, our studies provide at least three ways of overcoming original antigenic sin.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2012年第34期|13751-13756|共6页
作者
Kim J.H.; Davis W.G.; Sambhara S.Jacob J.;
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作者单位

Department of Microbiology and Immunology, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, United States;

Influenza Division, National Centers for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Antigen presentation; Cross-reactivity; Memory T-cell activation;

Strategies to alleviate original antigenic sin responses to influenza viruses

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